Postdoctoral position - Stalled Replication Fork Recombination and Repair

Dr. Rajula Elango’s lab at the Genome Integrity & Structural Biology Laboratory (GISBL) at the National Institute of Environmental Health Sciences (NIEHS) will open its doors in January 2024. The Elango lab will work on defining the rules that govern the processing, repair, and restart of stalled/broken mammalian replication forks and determine the contributions of various DNA repair pathways to genomic integrity.

The Elango lab will use mammalian cells (mouse embryonic stem cells) to explore the genetic requirements of a recently identified novel role for the Fanconi anemia (FA) pathway in the repair of a deleterious DNA lesion, DNA-protein crosslinks (DPCs) (Elango et al., NSMB, 2022). We will do this by using various cutting-edge techniques including CRISPR/Cas9 mediated gene-engineering and high-throughput sequencing techniques. These studies will allow us to exploit one or multiple steps of this repair pathway as a promising new target for therapy.

The Elango lab has openings for two Postdoctoral candidates.

• Postdoctoral candidates must have a Ph.D. degree in Biological Sciences or a related discipline within the last 5 years, with a strong background in genetics and molecular biology. The candidates must have strong communications skills, both oral and written, and have peer-reviewed publications in reputable journals.

Salary and Benefits: Postdoctoral candidates will be offered a competitive stipend/salary based on the number of years of relevant research experience. Health insurance is included in benefits. US visas can be sponsored for eligible candidates.

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

The Elango lab is committed to facilitate an inclusive and diverse work environment.