Senior Scientist - In Vivo Immunology

We are looking for a Senior Scientist to join the In vivo Bioscience team within Research and Early Development, Respiratory & Immunology (R&I) in Gothenburg, Sweden. This is a great opportunity to be part of a highly dynamic team that works closely with other departments, focusing on Translational Science, Bioscience In vitro, Cell Therapy, and Drug Metabolism/Pharmacokinetics, to support drug discovery projects and drive new exciting research. Respiratory & Immunology is one of AstraZeneca’s main therapy areas. From a research perspective, we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases. In this role, you will mainly focus on mouse models of inflammatory bowel disease (IBD). What you’ll do? As a Senior Scientist you are a vital member of the in vivo community and you will contribute to identifying novel targets and progress drug discovery projects. You will actively take part in scientific discussions, represent the department in project meetings and gain input from other functions to incorporate in vitro, pharmacokinetic and translational data into the experimental design. This is a partially lab-based role where you will design, plan, execute and analyze pre-clinical in vivo studies with a specific focus on IBD models. You will independently assess and report data from in vivo studies with a clear understanding of its reliability, interpret findings and plan next steps. In this role you are an immunology expert, able to give advice and influence critical decisions to move projects forward. To strengthen team capabilities, you will lead internal and external collaborations (academic partners and CROs).

Essential for the role PhD in immunology, ideally complemented by postdoctoral and/or industry experience. Profound knowledge in innate and adaptive immunity in the context of autoimmune and autoinflammatory diseases. Hands-on ability to independently design and perform in vivo disease and mechanistic models with a particular focus on gut immunology and IBD Experience with in vivo adoptive T cell transfer (naïve, Treg, CAR T) and subsequent ex vivo analysis. At last 5 years of experience with regular FACS analysis of mouse samples (organ processing and digestion, cell staining, antibody panel set up, proficient in the use of BD FACS DIVA machines and Flowjo). Experience with various cellular and molecular biology techniques for measuring proteins and gene expression to analyze ex vivo samples generated from in vivo studies. Experience in maintaining the highest standards of animal welfare and ethical compliance. Familiar with using Good Statistical Practice in animal research and applying the 3R’s. The successful candidate needs to show great time management and interpersonal skills in combination with excellent written and oral communication skills in English. Desirable for the role Valid education required for compliance to work with live animals in Sweden. Good understanding of pharmacology and PK/PD relationship in the context of in vivo studies. Good written and oral communication skills in Swedish and experience in writing ethical applications for animal work in Sweden. Experience in sorting cells at BD Cell Sorters. Understanding practical aspects of the drug discovery process in the pharma industry.