Job
Staff Scientist 1
Organization
National Human Genome Research Institute, Bethesda, MD and surrounding area
Scientific focus area
Genetics and Genomics, Cell Biology
The National Human Genome Research Institute (NHGRI), a major research component of the National Institutes of Health (NIH), and the Department of Health and Human Services (DHHS), is seeking exceptional candidates for a Staff Scientist position in the Metabolism, Infection & Immunity Section (MINIS), Metabolic Medicine Branch (MMB). MINIS research interest surrounds genetics, pathophysiology and treatment of hereditary mitochondrial disorders.
About the position
The Staff Scientist will:
- Lead experimental studies of mitochondrial function and bioenergetics in human tissues and cellular models;
- Develop and optimize assays of oxidative phosphorylation, respiratory chain activity and organization, and mitochondrial cellular phenotypes;
- Analyze and interpret experimental data;
- Maintain rigorous standards for assay quality and reproducibility;
- Oversee the organization, inventory, storage, tracking, and stewardship of protocol-derived biospecimens in accordance with applicable regulatory, institutional, and research protocol requirements.
The Staff Scientist will also mentor junior staff and collaborate with NHGRI and other investigators on studies of mitochondrial dysfunction in human disease.
Salary will be commensurate with education and experience.
Apply for this vacancy
What you'll need to apply
Applicants should send curriculum vitae and three letters of recommendation to the Administrative Officer: [email protected]
Contact name
Jeremy Alcorn
Contact email
Qualifications
Candidates must have a Ph.D. and a minimum of four years of postdoctoral or equivalent research experience in mitochondrial biology, bioenergetics, or a related field.
Candidates should have demonstrated expertise in the design and execution of mitochondrial functional studies using human tissue samples, including extracellular flux analysis, high-resolution respirometry using Oroboros platforms, in-gel respiratory chain complex activity assays, blue native PAGE (BN-PAGE), analysis of respiratory chain super complex formation, and flow cytometry.
Experience with mammalian cell culture, including the generation, maintenance, and experimental use of mitochondrial DNA-depleted rho-zero (ρ0) cells, is also desirable.
Additional experience working with primary human tissues, isolated mitochondria, permeabilized cells, and complementary biochemical or molecular assays is highly desirable.
Disclaimer/Fine Print
U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.
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