Staff Scientist

Prospective candidates will join a multidisciplinary team of biophysicists, cell biologists, and structural biologists exploring the mechanisms that govern Cl− homeostasis within intracellular organelles (such as lysosomes) and how dysregulation of this homeostasis contributes to neuropathology.

Candidates will be expected to plan, execute, and lead independently designed, peer-reviewed projects investigating the biophysics of organellar chloride transport and its physiological and pathophysiological roles in neurons. Candidates will also develop and apply advanced techniques to measure Cl− dynamics and transport across organellar membranes, including electrophysiology of organelles, fluorescence-based ion imaging, and spectroscopy.

This staff scientist will also be expected to employ electrophysiology, live-cell imaging, and other methods to elucidate molecular mechanisms of chloride channels/transporters in organelles. Lastly, candidates will design and implement in vitro and in vivo experiments, analyze data, interpret results, and publish findings in high-impact journals, as well as mentor and supervise trainees, postdocs, and junior laboratory staff.

Prospective applicants should have a Ph.D. in Biophysics, Neuroscience, Cell Biology, Biochemistry, Biomedical Engineering, and/or a closely related field. Applicants should also have 5 years of postdoctoral research experience with a demonstrated track record conducting independent research. First-author publications in peer-reviewed journals that demonstrate expertise in organellar biology, ion transport, or biophysical methods are highly desired.

Strong technical expertise in organellar electrophysiology or patch-clamp techniques, as well as live-cell imaging of Cl− dynamics (Cl−-sensitive indicators, genetically encoded sensors), ion channel/transport kinetics, and protein expression/purification is required. Proficiency in mammalian and insect cell culture, protein interaction assays, and data analysis using Python, MATLAB, R, is also required. Experience with structural methods (such as cryo-EM, X-ray crystallography) and/or computational modeling is highly desirable.

Excellent communication and collaborative skills, as well as the ability to work effectively in a multidisciplinary, team-based environment, is necessary.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.