Postdoctoral Fellow

Prospective postdoctoral fellows will work as part of a multidisciplinary team of innovative scientists to develop and apply NMR methods in the identification and validation of small molecules to advance various NCATS projects. They will also utilize advanced NMR techniques such as ligand-protein binding to explore the disruption of protein-protein interactions and residual dipolar coupling analysis for determination of structural conformation and configuration.

As such, candidates must have expertise in solution-state NMR spectroscopy with experience analyzing small molecules and/or proteins. Our NMR laboratory manages several high-field NMR spectrometers capable of performing experiments for structural identification and validation, impurity analysis, concentration determination, conformational analysis, ligand-protein binding, and epitope mapping.

Furthermore, this fellow will have the opportunity to be involved in the development of a fragment screening program. These research initiatives will require proficiency in sample preparation of various modalities prior to analysis.

This postdoctoral fellow will also be expected to work independently as a well-trained problem solver in the area of NMR spectroscopy. They will gain experience in NMR instrument troubleshooting and maintenance, including periodic cryogen fills (nitrogen weekly and helium quarterly), as well as the utilization of automation and a laboratory information management system for sample and data management. The fellow will be required to keep accurate and complete electronic records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will also draft technical reports, manuscripts and patent applications, as well as present work at internal and external meetings.

Prospective applicants must possess a Ph.D. in analytical chemistry, medicinal chemistry, biochemistry, biophysics, or related discipline, with a focus in NMR spectroscopy and/or have relevant research experience. Candidates should also possess extensive solution-state NMR experience, including sample preparation, data acquisition, and data analysis. Direct experience with NMR spectroscopy instrumentation (Bruker, JEOL, and/or Agilent) is a must.

Familiarity with data acquisition software (TopSpin, Delta, VnmrJ) and data processing software (Mnova, ACDLabs) will also be necessary. Training in the areas of conformational analysis, protein NMR, fragment screening, target engagement, and/or automation is desirable, but not required.

The ideal candidate will be self-motivated, possess a strong work ethic, and have keen attention to detail to be able to work on multiple projects simultaneously. Excellent analytical, organizational, and time-management skills are thus required. The candidate should also possess strong oral and written communication skills with a proven publication record in peer-reviewed journals.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.